Evaluating the Diagnostic Value of Three Early Cardiac Markers (Myoglobin, IMA and Copeptin) in STEMI patients
Erdem Çevik1, Banu Karakuş Yılmaz2, Yahya Ayhan Acar3, Aylin Haklıgör4, Orhan Çınar5
1Van Military Hospital Van / Turkey
2Department Of Emergency Medicine, Bagcilar Training And Research Hospital Istanbul / Turkey
3Etimesgut Military Hospital Ankara / Turkey
4Dr.ı.sevki Atasagun Nevsehir State Hospital Nevsehir / Turkey
5Gulhane Military Medical Academy Department Of Emergency Medicine Ankara / Turkey
Keywords: acute coronary syndrome, cardiac marker, copeptin, IMA, myoglobin
Abstract
Objectives: The aim of this study is to contribute the determining of the ideal early marker by evaluating them in cardiac troponin (cTn) negative ST segment elevation myocardial infarction (STEMI) patients.
Material and Methods: STEMI patients admitted to emergency department with chest pain were enrolled to the study. Venous blood samples were obtained early after admission in order to measure cTnI, creatine kinase MB (CK-MB) mass, myoglobin, ischemia modified albumin (IMA) and copeptin levels Patients’ demographics and electrocardiogram (ECG) findings were recorded.
Results: Twenty six STEMI patients were enrolled to the study. Four of them had normal cTnI levels at admission. Although copeptin levels were elevated in all of the patients, myoglobin levels were elevated in none of them and IMA levels were elevated in just one patient. The sensitivity of cTn increased from 84% to 100% with copeptin, %84 to %88 with IMA. There was no increase in cTn sensitivity with myoglobin.
Conclusion: It was determined that copeptin levels were elevated in earlier period in STEMI patients rather than IMA and myoglobin. These findings support the concomintant use of cTn and copeptin in early phase of STEMI.